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Vitamin D, cholecalciferol, ergocalciferol


Chemistry
vitamin D (cholecalciferol) is stable to heat, light and storage
vitamin D2 (ergocalciferol) is obtained from plants
vitamin D3 is cholecalciferol derived from animal products
1,25 DHCC is the most active form

Metabolism

Vitamin D is synthesized in the skin with ultraviolet light.

Functions

Vitamin D increases the absorption of calcium, increases the resorption of calcium into bone, and increases serum calcium levels.

Requirements
adults - 200 iu, children - 400 iu
labs - 10-80 ng/ml cholecalciferol, 21-45 pg/ml 1,25 DHCC

Sources
cod liver oil, mushrooms

Labs
decreased 25 HCC
increased alk phos suggests bone loss
decreased serum phosphorous

Toxicity
headache, weakness, N/V, constipation, polyuria, polydipsia, diarrhea
calcification of soft tissue - kidneys, lungs, tympanic membrane

Interactions
prednisone - decreases vitamin D
dilantin - interferes with vitamins D and K
olestra - inhibits the absorption of fat soluble vitamins

Deficiency
Rickets
in children, malformation of bones
stunted growth, Òknock kneesÓ
estlessness, poor sleep
Osteomalacia
in adults, skeletal demineralization
burning mouth and throat, nervousness, diarrhea, insomnia

Therapeutics
Musculoskeleta
l osteoporosis, rickets, fractures
Oncology
cancer prophylaxis
Dermatology
psoriasis - 1,25 DHCC has been found to be very helpful

 

 

 

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