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Vitamin B5, Pantothenic Acid


Pantothine, Pantothenic Acid

Metabolism
pantothenic acid -> pantothiene -> CoA -> Acetyl CoA

Function
CoA is involved in the Kreb cycle (ATP production)
part of acyl carrier protein, ACP (fat and cholesterol synthesis)
provides acetyl groups to form ACh (nerve impulse transmission)
essential for the formation of porphyrin (hemoglobin synthesis)
required for the formation of some steroids via the action of CoA

Requirements
RDA - none
Optimal - 100 mg

Sources
beef liver and kidney, chicken liver

Toxicity
diarrhea with very large doses

Deficiency
uncommon
Neurology
insomnia, depression, easy fatigue
leg cramps, parasthesia of the hands and feet
GI
GI disturbance
Respiratory
URI's

Therapeutics
Endocrine
adrenal insufficiency, stress
Musculoskeletal
osteoarthritis, rheumatoid arthritis
Dermatology
contact dermatitis, eczema
Hematology
anemia
Cardiovascular
atherosclerosis
Immune
allergies, systemic lupus



 

 

 

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