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Vitamin B2, Riboflavin


Vitamin B2, Riboflavin

Metabolism
Riboflavin is absorbed in the upper GI tract and turns urine bright yellow when excreted

Functions
Riboflavin is involved in the production of FMN and FAD (redox reactions)
Riboflavin activates Vitamin B6
Riboflavin is involved in the conversion of tryptophan to niacin
Riboflavin is involved in conversion of folate to its coenzymes
Riboflavin aids in beta oxidation (fat metabolism)
coenzyme of dehydrogenases (glucose metabolism)
Riboflavin is needed for the production of corticosteroids, erythropoesis
gluconeogenesis, and thyroid enzyme regulation

Requirements
RDA - 1.2-1.6 mg qd, Optimal - 5-15 mg qd

Sources
beef kidney and liver

Toxicity
None noted

Interactions
Synthroid decreases absorption
Tetracyclin and thiazide diuretics increase urinary excretion
Probenecid increases excretion and decreases absorption
Sulfonamides depress bacterial synthesis
Birth control pills are associated with reduced serum levels
Andriomycin interferes with function

Deficiency
Classic Signs of riboflavin deficiency are cheilosis and glossitis

EENT
sore throat, hyperemia and edema of the oral mucous membranes
cheilosis, angular stomatitis, glossitis
itchy eyes and photosensitivity
Dermatology
seborrheic dermatitis (dry and scaly skin)
Hematology
normochromic, normocytic anemia
due to red cell hypoplasia of the bone marrow.

Therapeutics
Dermatology
acne rosacea
Hematology
anemia
EENT
cataracts
Neurology
depression, migraine

 

 

 

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