Vitamin B12, Cobalamin, Methylcobalamin
Cobalamin is poorly absorbed without intrinsic factor
The hydroxy form is more easily absorbed than the cyano form
HCl and pepsin are needed to release it from food
Cobalamin is a cofactor for:
homocysteine -> methionine
methyl malonyl CoA -> succinyl CoA -> 2A3K Adipate -> Heme
cofactor in the transfer of methyl groups
required for DNA synthesis
involved in carbohydrate metabolism
RDA - 3 mcg
The Schilling test involves ingestion of radioactive B12
24 hour urine test for methyl malonic acid
serum microbial assay or RIA
beef liver, clams
In food, B12 is destroyed by large amounts of vitamin C
Cobalamin may cause pain when injected in some people
classic pernicious anemia due to lack of intrinsic factor
progressive peripheral neuropathy with pronounced anemia
fatigue, depression, confusion, memory loss, psychosis
anemia - cofactor for the production of Heme and DNA synthesis
deficiency causes megaloblast formation and megaloblastic anemia
sciatica, neuralgia, diabetic neuropathy
fatigue, insomnia, depression
acute viral hepatitis - studies show that it reduces the duration
psoriasis, seborrheic dermatitis, acne, dermatitis, canker sores
herpes zoster - IM injections reduce pain
bursitis - IM injections reduce pain and calcification
xanthelasma (fatty deposits on the lower eyelids)
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