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Vitamin B12, Cobalamin, Methylcobalamin


Cobalamin

Metabolism
Cobalamin is poorly absorbed without intrinsic factor
The hydroxy form is more easily absorbed than the cyano form
HCl and pepsin are needed to release it from food

Biochemistry
Cobalamin is a cofactor for:
homocysteine -> methionine
methyl malonyl CoA -> succinyl CoA -> 2A3K Adipate -> Heme

Functions
cofactor in the transfer of methyl groups
required for DNA synthesis
involved in carbohydrate metabolism

Requirements
RDA - 3 mcg

Labs
The Schilling test involves ingestion of radioactive B12
24 hour urine test for methyl malonic acid
serum microbial assay or RIA

Sources
beef liver, clams

Interaction
In food, B12 is destroyed by large amounts of vitamin C

Toxicity
Cobalamin may cause pain when injected in some people


Deficiency
Hematology
classic pernicious anemia due to lack of intrinsic factor
Neurology
progressive peripheral neuropathy with pronounced anemia
fatigue, depression, confusion, memory loss, psychosis
spinal degeneration
GI
glossitis, achlorhydria,

Therapeutics
Hematology
anemia - cofactor for the production of Heme and DNA synthesis
deficiency causes megaloblast formation and megaloblastic anemia
Neurology
sciatica, neuralgia, diabetic neuropathy
fatigue, insomnia, depression
Immune
allergies
acute viral hepatitis - studies show that it reduces the duration
Dermatology
psoriasis, seborrheic dermatitis, acne, dermatitis, canker sores
herpes zoster - IM injections reduce pain
Musculoskeletal
bursitis - IM injections reduce pain and calcification
EENT
xanthelasma (fatty deposits on the lower eyelids)

 

 

 

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A Brief Introduction to Naturopathy and Naturopathic Medicine describes the history and modalities. It's also FREE.

 


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