Nitric Oxide, NO
Nitric oxide (NO) is a key biological messenger that is also known as the Òendothelium-derived relaxing factorÓ, or ÒEDRF'.
NO is biosynthesised from arginine and oxygen by various nitric oxide synthase (NOS) enzymes and by reduction of inorganic nitrate.
Nitric oxide signals the endothelium (inner lining) of blood vessels to relax surrounding smooth muscle, thus dilating the artery and increasing blood flow.
Nitroglycerin and amyl nitrite are vasodilators because they convert into nitric oxide. Sildenafil (Viagra) stimulates erections primarily by enhancing signalling through the nitric oxide pathway in the penis.
Most "nitric oxide" supplements contain the amino acid Arginine-alpha-keto-glutarate.
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