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Ipriflavone, 7-isopropoxyisoflavone


Ipriflavone is a soy derived isoflavone, also called 7-isopropoxyisoflavone. It is a synthetic derivative of the plant isoflavone, genistein. Ipriflavone is found naturally in bee propolis.

Ipriflavone may have a beneficial action on bone density.


Ipriflavone is a derivative of the soy isoflavone genestein. Isoflavone is recommended to increase bone density and prevent osteoporosis.

For many years, ipriflavone has been a prescription medication (Osteofix 200) for osteoporosis in Italy. Lymphocytopenia (decreased white blood cells) is listed as a contraindication on the Osteofix 200 label.

Susan E. Brown, PhD, CCN, director of the Osteoporosis Education Project, has a very informative article about ipriflavone at

Dr. Brown found 31 human clinical studies on ipriflavone published from 1989 through April 2000. 18 studies were placebo-controlled. About half of the placebo-controlled studies show that ipriflavone increases bone density or reduces bone loss more effectively than calcium alone.

A multi-centered (Belgium, Denmark, Italy) three-year European study (IMEFS) reported less encouraging results.

Dr. Brown's own experience with patients at her clinic indicates that "ipriflavone is generally effective at halting bone loss in postmenopausal women who are undergoing excessive bone loss." As a possible explanation for the IMEFS' negative results, Dr. Brown says that "ipriflavone ... may well not do very much for those who are not actively losing bone, even though they may have osteoporosis."




Fantastic new books!

CAM Therapies has studies on natural therapies for over 100 diseases.

CAM Labs lists lab tests for 100 diseases.

Nutritional Genetics is a fantastic resource.



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