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Alpha Lipoic Acid, Alpha-Lipoic Acid, Thioctic acid


Alpha-lipoic acid (LA), also known as thioctic acid, is an anti-oxidant. It can reduce the oxidized forms of vitamin C, glutathione, CoQ10 and alpha-tocopherol.

Functions
antioxidant, detoxification, supports the liver
reverses amanita poisoning

Uses
hepatitis
Diabetes mellitus


Conventional chemical synthesis of alpha-lipoic acid results in a 50/50 (racemic) mixture of its two optical isomers, R-alpha-lipoic acid (right optical isomer) and S-alpha-lipoic acid (left optical isomer). Only the R-form of alpha-lipoic acid is naturally occurring. Research comparing the efficacy of the two forms has produced data in favor of the R-form as being superior with respect to mitochondrial ATP synthesis, as the mitochondria appear to be more sensitive to the naturally occurring form. This initial research suggests that R-form alpha-lipoic acid may be 10 times more potent than its mirror isomer. In addition, when measuring plasma concentrations after oral administration of both forms, R-form alpha-lipoic acid has been measured at 40-50% higher than the S-form. Therefore, R-form lipoic acid may be a better value even though it is more expensive on a comparative milligram basis. Please note that R-form lipoic acid needs refrigeration.

The reduced form is known as dihydrolipoic acid (DHLA), while the oxidized form is known as Alpha-lipoic acid (LA).

 

 

 

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