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Rauwolfia serpentina, Indian snakeroot, Rauwolfia


Rauwolfia serpentina, Indian snakeroot

Description
Rauwolfia is native to India, where it is known as Sarpaganda, it was used for centuries to treat insanity as well as physical illnesses such as fevers and snakebites.
Rauwolfia is considered the most powerful hypotensive botanical. Only a small dose is required to achieve results and to avoid side effects. Nasal congestion is the most common side effect.

Actions
sedative, cardiac depressant - no effect on coronary blood flow

Uses
extreme HBP

Pharmacology
ajmaline - anti-arrythmic, regulates heart beat
Reserpine - lowers BP

Contraindications
toxic, cardiac depressant CI CHF, depression, peptic ulcer


Reserpine was isolated in 1952 from the dried root of Rauwolfia. After its isolation in 1952 it was used to lower high blood pressure, but its property of producing severe depression as a side effect also made it useful in psychiatry as a tranquilizer in the control of agitated psychotic patients. Reserpine causes many toxic side effects including nightmares, Parkinsonism, and gastrointestinal disturbances.

 

 

 

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