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Pycnogenol, PYC, Pinus maritimaDescription Pycnogenol (PYC) is a standardized extract of French maritime pine bark. Constituents Pycnogenol is primarily composed of procyanidins and phenolic acids. Actions Pycnogenol is an antioxidant and potent scavenger of free radicals. Pycnogenol helps in regeneration and protection of vitamin C and E Anti-inflammatory activity has been demonstrated in vitro and in vivo in animals Therapeutics Beneficial for chronic venous insufficiency and retinal micro-hemorrhages. Pycnogenol prevents smoking-induced platelet aggregation and reduces thromboxane. Pycnogenol inhibits angiotensin-converting enzyme, and has a mild antihypertensive effect. Protection against UV-radiation-induced erythema In asthma, it improves symptom scores, reduces circulating leukotrienes and improves lung function. Immunomodulation has been observed in both animal models as well as in patients with Lupus erythematosus. relieves premenstrual symptoms, including abdominal pain and this action may be associated with the spasmolytic action of some phenolic acids. An improvement in cognitive function has been observed in controlled animal experiments and these findings support anecdotal reports of improvement in ADHD patients taking PYC supplements. Dilation of the small blood vessels has been observed in patients with cardiovascular disease Pycnogenol antagonizes the vasoconstriction caused by epinephrine and norepinephrine by increasing the activity of endothelial nitric oxide synthase.
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