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Methionine, L-Methionine


Methionine

Metabolism
Methionine forms S-adenosyl methionine, SAM

Functions
Methionine is a sulfur donor
methyl donor
breakdown of estrogens and degradation of histamine
synthesis of carnitine, choline, creatine, epinephrine, melatonin
synthesis of nucleic acids
glutathione synthesis
antioxidant
maintains cartilage health

Requirements
RDA - adults - 1.5 g, children - 22 mg/kg

Sources
tuna, cheddar cheese, salmon

Deficiency
Methionine deficiency is usually related to overall protein malnutrition
SAM synthesis needs B-12, folate and methionine

Therapeutics
depression, schizophrenia
osteoarthritis, pain, fibromyalgia
allergies
Wilson's disease
Parkinson's, migraines
acrodermatitis enteropathica

Toxicity
rare, first signs are nausea and GI irritation
use caution in bipolar disorders as SAM may precipitate a manic phase




 

 

 

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