| Tinzaparin, Innohep
INNOHEP is a sterile solution, containing tinzaparin sodium, a low molecular weight heparin.
NNOHEP is indicated for the treatment of acute symptomatic deep vein thrombosis with or without pulmonary embolism when administered in conjunction with warfarin sodium.
Bleeding : Bleeding is the most common adverse event associated with INNOHEP (tinzaparin sodium injection); however, the incidence of major bleeding is low. In clinical trials, the definition of major bleeding included bleeding accompanied by ³2 gram/dL decrease in hemoglobin, requiring transfusion of 2 or more units of blood products, or bleeding which was intracranial, retroperitoneal, or into a major prosthetic joint.
Fatal or nonfatal hemorrhage from any tissue or organ can occur. The signs, symptoms, and severity will vary according to the location and degree or extent of the bleeding. Hemorrhagic complications may present as, but are not limited to, paralysis; dizziness; shortness of breath, difficult breathing or swallowing; swelling; weakness; hypoptension, shock, or coma. Therefore, the possibility of hemorrhage should be considered in evaluating the condition of any anticoagulated patient with complaints which do not indicate an obvious diagnosis
Elevations of Serum Aminotransferases
Hypersensitivity : Anaphylactic/anaphylactoid reactions may occur
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