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Theophylline, Theo-Dur

Description

Theophylline is a methylxanthine drug used for respiratory diseases such as COPD or asthma.

Theophylline was first extracted from tea leaves around 1888 by the German biologist Albrecht Kossel.

Action

bronchodilator, methylxanthine

Indications

asthma, bronchitis, bronchospasm, chronic obstructive pulmonary disease (COPD), methotrexate toxicity, neonatal apnea,

Side Effects

abdominal pain, agitation, anorexia, anxiety, atrial fibrillation, atrial flutter, atrial tachycardia, cardiac arrest, diuresis, dizziness, headache, hematemesis, hypokalemia, hypotension, insomnia, metabolic acidosis, nausea/vomiting, palpitations, premature ventricular contractions (PVCs), restlessness, seizures, sinus tachycardia, supraventricular tachycardia (SVT), urticaria, ventricular tachycardia,

Drug-Vitamin-Herb Interactions


Negative interactions:

Cayenne
Cayenne may increase absorption of theophylline, possibly leading to theophylline toxicity.

Ipriflavone
Ipriflavone appears to slow breakdown of theophylline, possibly leading to theophylline toxicity.

St JohnÕs Wort
St JohnÕs Wort can lower levels of theophylline making it less effective.


Positive interactions:

Vitamin B6
Theophylline impairs conversion of B6 into active P5P, which may cause deficiency.

 

 

 

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