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Tamoxifen, Nolvadex

Description

Tamoxifen is an estrogen receptor antagonist

Action

estrogen receptor antagonist

Indications

breast carcinoma, infertility, malignant melanoma, mastalgia, osteoporosis,

Side Effects

anemia, bone pain, cataracts, cholestasis, corneal deposits, corneal opacification, elevated hepatic enzymes, endometrial carcinoma, hepatic necrosis, hepatitis, hot flashes, hypercalcemia, hyperlipidemia, impotence, leukopenia, libido decrease, menstrual irregularity, nausea/vomiting, neutropenia, optic neuritis, pulmonary embolism, retinopathy, thrombocytopenia, vaginal bleeding, vaginal discharge, visual impairment,

Drug-Vitamin-Herb Interactions


Negative interactions:

Androstenedione
Androstenedione increases estrogen levels, which may increase the adverse effects of estrogen therapy.

Boron
Boron may increase estrogen levels, which may increase the adverse effects of estrogen therapy.

Dong quai
Dong quai contains beta-sitosterol, a phytoestrogen, which may increase the adverse effects of estrogen therapy. Studies, however, do not support this.

Grapefruit juice
Grapefruit juice slows breakdown of estrogen.


Mixed interactions:

Ipriflavone
Ipriflavone protects bone, but may increase estrogen effect on the uterus.


Positive interactions:

Calcium and Vitamin D
Calcium and Vitamin D aid in bone growth.

Magnesium
Magnesium metabolism is enhanced by estrogen, which may result in a deficiency.

 

 

 

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