Natural Health Research

Naturopathic Medicine
Health Quizzes
Sinemet, Levodopa with Carbodopa


Sinemet is Levodopa with Carbodopa. Levodopa converts to dopamine.


levodopa converts to dopamine


ParkinsonÕs disease

Side Effects

anorexia, ataxia, dystonia, flushing, hypertension, hyperventilation, involuntary movements, leukopenia, nausea/vomiting, neuroleptic malignant syndrome, orthostatic hypotension, polyuria, psychosis, tremor, urinary incontinence, urinary retention, weight loss,

Drug-Vitamin-Herb Interactions

Negative interactions:

The combination of 5-HTP and carbidopa may cause a scleroderma-like condition.

Branched Chain Amino Acids, BCAAs
Amino acids in dietary proteins decrease effectiveness of levodopa.

Iron interferes with absorption of carbodopa and levodopa. Take at separate times.

Kava may interfere with the action of dopamine.

Vitamin B6
Higher doses of Vitamin B6 can reduce the therapeutic effect of levodopa alone in ParkinsonÕs disease.

Mixed interactions:

Levodopa may deplete SAMe.




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