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Sinemet, Levodopa with Carbodopa

Description

Sinemet is Levodopa with Carbodopa. Levodopa converts to dopamine.

Action

levodopa converts to dopamine

Indications

ParkinsonÕs disease

Side Effects

anorexia, ataxia, dystonia, flushing, hypertension, hyperventilation, involuntary movements, leukopenia, nausea/vomiting, neuroleptic malignant syndrome, orthostatic hypotension, polyuria, psychosis, tremor, urinary incontinence, urinary retention, weight loss,

Drug-Vitamin-Herb Interactions


Negative interactions:

5-HTP
The combination of 5-HTP and carbidopa may cause a scleroderma-like condition.

Branched Chain Amino Acids, BCAAs
Amino acids in dietary proteins decrease effectiveness of levodopa.

Iron
Iron interferes with absorption of carbodopa and levodopa. Take at separate times.

Kava
Kava may interfere with the action of dopamine.

Vitamin B6
Higher doses of Vitamin B6 can reduce the therapeutic effect of levodopa alone in ParkinsonÕs disease.


Mixed interactions:

SAMe
Levodopa may deplete SAMe.

 

 

 

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