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Sertaline, Zoloft, Sertraline, Lustral, Apo-Sertral, Asentra


Sertaline selective serotonin reuptake inhibitor (SSRI) antidepressant, which is mainly to treat the symptoms of depression and anxiety.

Sertaline is also prescribed for the treatment of obsessive-compulsive disorder (OCD), post-traumatic stress disorder (PTSD), premenstrual dysphoric disorder (PMDD), panic disorder (PD) and social phobia/social anxiety disorder.

Unapproved uses include generalized anxiety disorder, binge eating disorder, and premature ejaculation.


SSRI, serotonin uptake inhibitor


major depression, obsessive compulsive disorder

Side Effects

agitation, mania, tremor, palpitations, dizziness, drowsiness, fatigue, insomnia, nausea/vomiting, constipation, diarrhea, dyspepsia, anorexia, headache, blurred vision, xerostomia, erythema, bullous rash, maculopapular rash, diaphoresis, hyponatremia, increased urinary frequency, SIADH, ejaculation dysfunction, orgasm dysfunction, elevated hepatic enzymes

Drug-Vitamin-Herb Interactions

Negative interactions:

5-HTP increases levels of serotonin, which increases the risk of serotonin syndrome.

SAMe increases levels of serotonin, which increases the risk of serotonin syndrome.

St JohnÕs Wort
St JohnÕs Wort may increase levels of serotonin, which increases the risk of serotonin syndrome.

Positive interactions:

Ginkgo biloba
Ginkgo may help reverse the sexual side effects of SSRIs, including inability to orgasm in women and impotence in men.




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