Reserpine is an indole alkaloid antipsychotic and antihypertensive drug known to irreversibly bind to storage vesicles of neurotransmitters such as dopamine, norepinephrine, and serotonin.
In theory, depletion of neurotransmitters causes depression in humans. However a 1950's drug trial at Maudsley Hospital found that in fact reserpine, far from causing depression, actually acted as an antidepressant.
Reserpine was isolated in 1952 from the dried root of Rauwolfia serpentina (Indian snakeroot).
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