Natural Health Research

Naturopathic Medicine
Health Quizzes
Ranitidine, Zantac


Ranitidine is a histamine H2-receptor antagonist that inhibits stomach acid production, and commonly used in the treatment of peptic ulcer disease (PUD) and gastroesophageal reflux disease (GERD).


H2 antagonist, decreases stomach acid


aspiration prophylaxis, duodenal ulcer, dyspepsia, esophagitis, gastric ulcer, gastroesophageal reflux disease (GERD), multiple endocrine adenoma syndrome, NSAID-induced ulcer prophylaxis, pyrosis (heartburn), stress gastritis prophylaxis, systemic mastocytosis, Zollinger-Ellison syndrome,

Side Effects

abdominal pain, agitation, alopecia, constipation, delirium, depression, diarrhea, dizziness, elevated hepatic enzymes, gynecomastia, hallucinations, headache, hepatitis, impotence, insomnia, jaundice, leukopenia, libido decrease, maculopapular rash, nausea/vomiting, pancreatitis, pancytopenia, paranoia, Stevens-Johnson syndrome, thrombocytopenia, toxic epidermal necrolysis,

Drug-Vitamin-Herb Interactions

Negative interactions:

Magnesium (often found in antacids) may reduce the absorption of H2 antagonists. Take at a different time of day.

Positive interactions:

Folate absorption is best in an acidic environment. H2 antagonists reduce stomach acid which can lower folate absorption.

Vitamin B12
Vitamin B12 absorption may be impaired by H2 antagonists, which reduce stomach acid.

Iron and Zinc
Iron and Zinc absorption is inhibited by reduced stomach acid levels.




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