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Prourokinase

Description

Prourokinase is a new fibrinolytic agent that is currently undergoing clinical trials for a variety of indications. It is a relatively inactive precursor that must be converted to urokinase before it becomes active in vivo. Its advantages over other plasminogen activators are that it is inactive in plasma and does not bind to or consume circulating inhibitors. As with tissue-type plasminogen activator, prourokinase is somewhat clot specific, since the presence of fibrin enhances the conversion of prourokinase to active urokinase by an unknown mechanism.


Action

thrombolytic

Indications



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Drug-Vitamin-Herb Interactions

 

 

 

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