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PremPro, PremPhase

Description

PremPro contains conjugated estrogens (CE) found in Premarin tablets and medroxyprogesterone acetate (MPA) for oral administration.

Action

Estrogens and Medroxyprogesterone

Indications

atrophic vaginitis, osteoporosis, menopausal symptoms

Side Effects



Drug-Vitamin-Herb Interactions


Negative interactions:

Androstenedione
Androstenedione increases estrogen levels, which may increase the adverse effects of estrogen therapy.

Boron
Boron may increase estrogen levels, which may increase the adverse effects of estrogen therapy.

Dong quai
Dong quai contains beta-sitosterol, a phytoestrogen, which may increase the adverse effects of estrogen therapy. Studies, however, do not support this.

Grapefruit juice
Grapefruit juice slows breakdown of estrogen.


Mixed interactions:

Ipriflavone
Ipriflavone protects bone, but may increase estrogen effect on the uterus.


Positive interactions:

Calcium and Vitamin D
Calcium and Vitamin D aid in bone growth.

Magnesium
Magnesium metabolism is enhanced by estrogen, which may result in a deficiency.

 

 

 

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