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Pilocarpine, Pilocar

Description

Pilocarpine is a muscarinic alkaloid obtained from the leaves of tropical American shrubs from the genus Pilocarpus. It acts as a muscarinic receptor agonist in the parasympathetic nervous system.

Pilocarpine has been used in the treatment of chronic open-angle glaucoma and acute angle-closure glaucoma for over 100 years.

Pilocarpine is also used to treat dry mouth (xerostomia). Pilocarpine stimulates the secretion of large amounts of saliva and sweat. It may also cause hypotension and bradycardia in the cardiovascular system, and bronchospasm and increased bronchial secretion in the lungs due to its non-selective muscarinic action.

Action

cholinergic muscarinic agonist

Indications

glaucoma, miosis induction, xerostomia,

Side Effects

abdominal pain, amblyopia, asthenia, blurred vision, bronchospasm, chills, ciliary spasm, diaphoresis, diarrhea, dizziness, dyspepsia, dysphagia, edema, epistaxis, flushing, headache, hypersalivation, hypertension, increased urinary frequency, lacrimation, miosis, myopia, nausea/vomiting, night blindness, ocular irritation, ocular pain, photophobia, retinal detachment, rhinitis, sinus tachycardia, tremor,

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