Natural Health Research

Naturopathic Medicine
Health Quizzes
Phenytoin, Dilantin, Epanutin


Phenytoin is a commonly used antiepileptic used in the treatment of seizures.


hyantoin type anticonvulsant


diabetic neuropathy, digoxin toxicity, migraine prophylaxis, neuropathic pain, paroxysmal atrial tachycardia, partial seizures, seizure prophylaxis, status epilepticus, tonic-clonic seizures, ventricular tachycardia,

Side Effects

abdominal pain, agranulocytosis, anorexia, aplastic anemia, ataxia, bullous rash, cholestasis, choreoathetosis, coma, constipation, dizziness, drowsiness, dystonia, elevated hepatic enzymes, exfoliative dermatitis, gingival hyperplasia, glomerulonephritis, granulocytopenia, hepatitis, hirsutism, hyperglycemia, hypertrichosis, hypotension, impotence, injection site reaction, interstitial nephritis, jaundice, lethargy, leukopenia, libido decrease, lupus-like symptoms, lymphadenopathy, maculopapular rash, megaloblastic anemia, nausea/vomiting, nephrotic syndrome, nystagmus, osteomalacia, pancytopenia, priapism, proteinuria, purpura, seizures, skin hyperpigmentation, Stevens-Johnson syndrome, thrombocytopenia, toxic epidermal necrolysis, vasculitis,

Drug-Vitamin-Herb Interactions

Negative interactions:

Ginkgo biloba
Ginkgo leaves contain small amounts of a natural nerve toxin.

Glutamine forms glutamate which acts as a neurotransmitter.

Grapefruit juice
Grapefruit juice slows the breakdown of several drugs, including carbamezapine.

Ipriflavone - inhibits breakdown of carbamezapine and phenytoin, may cause toxic build up

Sedative herbs (Kava, Valerian, Hops)
Sedative herbs may add to depressant side-effect of anticonvulsants.

Nicotinamide (Niacinamide) increases levels of carbamezapine and primidone, which may cause a toxic build up.

St JohnÕs Wort and Dong Quai
St JohnÕs Wort and Dong Quai may add to side effect of sun sensitivity.

Vitamin A
Valproic acid may interfere with the ability to handle vitamin A (beta carotene is fine).

White willow
High doses of aspirin increases phenytoin levels and toxicity. White willow contains salicylates (theoretical effect).

High levels of folate may increase breakdown of phenytoin (which may cause excess seizures)

Mixed interactions:

Anticonvulsants may deplete biotin by competeing for absorption. Take at different times of the day.

Anticonvulsants deplete folate.

Positive interactions:

Anticonvulsants impair calcium absorption. Take at different times of the day.

Anticonvulsants (especially valproic acid) deplete carnitine.

Vitamin D
Anticonvulsants may interfere with vitamin D activity and cause deficiency.

Vitamin K
Anticonvulsants speed up breakdown of vitamin K, leading to deficiency and bleeding.




Fantastic new books!

CAM Therapies has studies on natural therapies for over 100 diseases.

CAM Labs lists lab tests for 100 diseases.

Nutritional Genetics is a fantastic resource.



Information on this site is provided for informational purposes only and is not meant to substitute for the advice provided by your own physician or other medical professional. You should not use the information contained herein for diagnosing or treating a health problem or disease, or prescribing any medication. If you have or suspect that you have a medical problem, promptly contact your health care provider. Information and statements on this site have not been evaluated by the Food and Drug Administration.