| Phenobarbital, Phenobarbitone, Luminal
Phenobarbital is the most widely used anti-convulsant worldwide and the oldest still in use.
Phenobarbital is used to treat of all types of seizures except absence seizures.
anticonvulsant, barbiturate, sedative, hypnotic
acneiform rash, bullous rash, constipation, diarrhea, exfoliative dermatitis, hypotension, impotence, injection site reaction, insomnia, interstitial nephritis, learning impairment, lethargy, libido decrease, maculopapular rash, miosis, mydriasis, nausea/vomiting, nightmares, nystagmus, osteopenia, photosensitivity, ptosis, purpura, respiratory depression, sinus bradycardia, Stevens-Johnson syndrome, thrombophlebitis, toxic epidermal necrolysis, urticaria,
Ginkgo leaves contain small amounts of a natural nerve toxin.
Glutamine forms glutamate which acts as a neurotransmitter.
Grapefruit juice slows the breakdown of several drugs, including carbamezapine.
Ipriflavone - inhibits breakdown of carbamezapine and phenytoin, may cause toxic build up
Sedative herbs (Kava, Valerian, Hops)
Sedative herbs may add to depressant side-effect of anticonvulsants.
Nicotinamide (Niacinamide) increases levels of carbamezapine and primidone, which may cause a toxic build up.
St JohnÕs Wort and Dong Quai
St JohnÕs Wort and Dong Quai may add to side effect of sun sensitivity.
Valproic acid may interfere with the ability to handle vitamin A (beta carotene is fine).
High doses of aspirin increases phenytoin levels and toxicity. White willow contains salicylates (theoretical effect).
High levels of folate may increase breakdown of phenytoin (which may cause excess seizures)
Anticonvulsants may deplete biotin by competeing for absorption. Take at different times of the day.
Anticonvulsants deplete folate.
Anticonvulsants impair calcium absorption. Take at different times of the day.
Anticonvulsants (especially valproic acid) deplete carnitine.
Anticonvulsants may interfere with vitamin D activity and cause deficiency.
Anticonvulsants speed up breakdown of vitamin K, leading to deficiency and bleeding.
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