Natural Health Research

Naturopathic Medicine
Health Quizzes
Penicillamine, Cuprimine, Depen


Penicillamine is a chelator that binds to copper.


binds to copper, used in WilsonÕs disease


WilsonÕs disease

Side Effects

abdominal pain, agranulocytosis, anorexia, aplastic anemia, arthralgia, bleeding, chills, cough, diarrhea, diplopia, dysgeusia, dyspnea, exfoliative dermatitis, fever, glomerulonephritis, hematuria, hemolysis, leukopenia, maculopapular rash, myasthenia, nausea/vomiting, nephrotic syndrome, optic neuritis, pancytopenia, peripheral neuropathy, proteinuria, pruritus, stomatitis, thrombocytopenia, tinnitus, urticaria, wheezing,

Drug-Vitamin-Herb Interactions

Negative interactions:

Those with WilsonÕs disease should avoid copper

Iron may interfere with absorption. Take at a different time of day.

Magnesium may reduce with absorption. Take at a different time of day.

Positive interactions:

Vitamin B6
Penacillamine can deplete vitamin B6.




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