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Naturopathic Medicine
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Olanzapine, Zyprexa, Zydis


Olanzapine was the second atypical antipsychotic approved by the FDA.


atypical antipsychotic


Olanzapine has been approved by the FDA for the treatment of schizophrenia, acute mania in bipolar disorder, agitation associated with schizophrenia and bipolar disorder, and as maintenance treatment in bipolar disorder and psychotic depression.

Side Effects

drowsiness was the most frequent ADR (50%) in a small open label trial; extrapyramidal reactions and degree of hyperprolactinemia appear to be low; agranulocytosis has not yet been reported.

Drug-Vitamin-Herb Interactions

Negative interactions:

Kava may block dopamine worsening movement disorder side effects, may cause excess sedation.

Phenylalanine may worssen the side effect of tardive dyskinesia associated with antipsychotic medications.

St JohnÕs Wort
St JohnÕs Wort accelerates breakdown of olanzapine (Zyprexa) and clozapine (Clozaril).

St JohnÕs Wort and Dong quai
St JohnÕs Wort and Dong quai can cause sensitivity to sun, adding to the side effects of antipsychotic agents.

Sedative herbs: Kava, Passionflower, Hops, Ashwagandha, Calendula, Catnip, LadyÕs Slipper, Lemon Balm, Sassafras, Skullcap, and Yerba mansa.
Sedative herbs may cause excess sedation when used with antipsychotic agents.

Phenothiazines may increase yohimbe toxicity.

Positive interactions:

Coenzyme Q10
Phenothiazines inhibit enzymes containing CoQ10.

Ginkgo biloba
Ginkgo may help reduce side effects and increase efficacy of antipsychotic medications.

Milk Thistle
Milk Thistle may protect the liver against toxicity caused by phenothiazide drugs.

Vitamin E
Vitamin E may help treat and prevent tardive dyskenisia (a side effect of phenothiazide drugs).




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