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Nifedipine, Procardia, Adalat

Description

Nifedipine is a dihydropyridine calcium channel blocker. Its main uses are in angina pectoris (especially Prinzmetal's angina) and hypertension, although a large number of other uses have recently been found for this agent, such as Raynaud's phenomenon, premature labor, and painful spasms of the esophagus in cancer patients.

Nifedipine lowers the blood pressure rapidly, and patients are commonly warned they may feel dizzy or faint after taking the first few doses. Tachycardia (fast heart rate) may occur as a reaction. These problems are much less frequent in the sustained-release preparations of nifedipine (such as Adalat OROS).

Nifedipine should be taken on an empty stomach, and patients are warned not to consume anything containing grapefruit or grapefruit juice, as it lowers CYP3A4 activity (the enzyme that digests nifedipine) and may lead to increased levels of nifedipine or other medications that are metabolised by CYP3A4 in the blood.

Action

calcium-channel blocker

Indications

angina, diabetic nephropathy, hiccups, hypertension, hypertensive emergency, hypertensive urgency, migraine prophylaxis, Prinzmetal's angina, proteinuria,

Side Effects

asthenia, dizziness, dyspnea, flushing, glomerulonephritis, headache, heart failure, hypotension, palpitations, peripheral edema, photosensitivity, sinus tachycardia, syncope, vertigo, weakness

Drug-Vitamin-Herb Interactions


Negative interactions:

Calcium and Vitamin D
Calcium and Vitamin D may counteract the action of calcium-channel blockers.

Grapefruit juice
Grapefruit juice inhibits the breakdown of several drugs, including calcium channel blockers.

 

 

 

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