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Minoxidil, Loniten

Description

Minoxidil tablets contain minoxidil, an antihypertensive peripheral vasodilator. It is also approved for androgenic alopecia.

Action

stimulates hair growth, peripheral vasodilator

Indications

Minoxidil tablets contain minoxidil, an antihypertensive peripheral vasodilator. It is also approved for androgenic alopecia.

Side Effects

Salt and Water Retention
Temporary edema developed in 7% of patients who were not edematous at the start of therapy. (Concomitant Use of an Adequate Diuretic is Required)
Pericarditis, Pericardial Effusion, and Temponade

Hypertrichosis: Elongation thickening and enhanced pigmentation of fine body hair are seen in about 80% of patients taking minoxidil tablets. This develops within 3 to 6 weeks after starting therapy. It is usually first noticed on the temples, between the eyebrows, between the hairline and the eyebrows, or in the side-burn area of the upper lateral cheek, later extending to the back, arms, legs and scalp. Upon discontinuation of minoxidil, new hair growth stops, but 1 to 6 months may be required for restoration to pretreatment appearance. No endocrine abnormalities have been found to explain the abnormal hair growth; thus it is hypertrichosis without virilism. Hair growth is especially disturbing to children and women and such patients should be thoroughly informed about this effect before therapy with minoxidil is begun.

Allergic: Rashes have been reported including rare reports of bullous eruptions, and Stevens-Johnson Syndrome.

Hematologic

Thrombocytopenia and leukopenia (WBC<3000/mm3) have rarely been reported.

Gastrointestinal

Nausea and/or vomiting has been reported. In clinical trials the incidence of nausea and vomiting associated with the underlying disease has shown a decrease from pretrial levels.

Miscellaneous

Breast Tenderness: This developed in less than 1% of patients.

Altered Laboratory Findings

ECG changes: Changes in direction and magnitude of the ECG T-waves occur in approximately 60% of patients treated with minoxidil. In rare instances a large negative amplitude of the T-wave may encroach upon the S-T segment, but the S-T segment is not independently altered. These changes usually disappear with continuance of treatment and revert to the pretreatment state if minoxidil is discontinued. No symptoms have been associated with these changes, nor have there been alterations in blood cell counts or in plasma enzyme concentrations that would suggest myocardial damage. Long-term treatment of patients manifesting such changes has provided no evidence of deteriorating cardiac function. At present the changes appear to be nonspecific and without idendifiable clinical significance.

Effects of Hemodilution: Hematocrit, hemoglobin and erythrocyte count usually fall about 7% initially and then recover to pretreatment levels.

Other: Alkaline phosphatese increased varyingly without other evidence of liver or bone abnormality. Serum creatinine increased an average of 6% and BUN slightly more, but later declined to pretreatment levels.

Drug-Vitamin-Herb Interactions

 

 

 

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