| Methotrexate, Folex PFS, Immunex, Rheumatrex
folic acid analog, inhibits human dihydrofolate reductase
cytotoxic - inhibits DNA synthesis in the S-phase
inhibits replication and function of T cells
anti-neoplastic, folic acid analog
acute lymphocytic leukemia (ALL), asthma, biliary cirrhosis, bladder carcinoma, breast carcinoma, Burkitt's lymphoma, carcinomatous meningitis, choriocarcinoma, Crohn's disease, dermatomyositis, graft-versus-host disease, hydatidiform mole, mycosis fungoides, non-Hodgkin's lymphoma, osteogenic sarcoma, ovarian carcinoma, polymyositis, pregnancy termination, pruritus, psoriasis, rheumatoid arthritis, sarcoidosis, squamous cell carcinoma of the head and neck,
alopecia, anemia, anorexia, arachnoiditis, azotemia, cirrhosis, crystalluria, diarrhea, elevated hepatic enzymes, GI bleeding, GI perforation, gingivitis, glossitis, hematemesis, hematuria, leukoencephalopathy, leukopenia, nausea/vomiting, neutropenia, ocular irritation, pancytopenia, paresis, pharyngitis, photosensitivity, pruritus, pulmonary fibrosis, renal intratubular obstruction, stomatitis, thrombocytopenia, urticaria,
Potassium citrate (and other citrates) make urine less acidic, which decreases levels of methotrexate.
St JohnÕs Wort
St JohnÕs Wort may cause sensitivity to sunlight, adding to the side effects of many drugs.
Dong Quai may cause sensitivity to sunlight, adding to the side effects of many drugs.
Salicylates may increase methotrexate levels and toxicity.
Folate decreases side effects and increases efficacy in those with arthritis or psoriasis.
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