Natural Health Research

Naturopathic Medicine
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Methotrexate, Folex PFS, Immunex, Rheumatrex


anti-neoplastic, immunosuppressant
folic acid analog, inhibits human dihydrofolate reductase
cytotoxic - inhibits DNA synthesis in the S-phase
inhibits replication and function of T cells


anti-neoplastic, folic acid analog


acute lymphocytic leukemia (ALL), asthma, biliary cirrhosis, bladder carcinoma, breast carcinoma, Burkitt's lymphoma, carcinomatous meningitis, choriocarcinoma, Crohn's disease, dermatomyositis, graft-versus-host disease, hydatidiform mole, mycosis fungoides, non-Hodgkin's lymphoma, osteogenic sarcoma, ovarian carcinoma, polymyositis, pregnancy termination, pruritus, psoriasis, rheumatoid arthritis, sarcoidosis, squamous cell carcinoma of the head and neck,

Side Effects

alopecia, anemia, anorexia, arachnoiditis, azotemia, cirrhosis, crystalluria, diarrhea, elevated hepatic enzymes, GI bleeding, GI perforation, gingivitis, glossitis, hematemesis, hematuria, leukoencephalopathy, leukopenia, nausea/vomiting, neutropenia, ocular irritation, pancytopenia, paresis, pharyngitis, photosensitivity, pruritus, pulmonary fibrosis, renal intratubular obstruction, stomatitis, thrombocytopenia, urticaria,

Drug-Vitamin-Herb Interactions

Negative interactions:

Potassium citrate
Potassium citrate (and other citrates) make urine less acidic, which decreases levels of methotrexate.

St JohnÕs Wort
St JohnÕs Wort may cause sensitivity to sunlight, adding to the side effects of many drugs.

Dong Quai
Dong Quai may cause sensitivity to sunlight, adding to the side effects of many drugs.

White Willow
Salicylates may increase methotrexate levels and toxicity.

Positive interactions:

Folate decreases side effects and increases efficacy in those with arthritis or psoriasis.




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