Natural Health Research

Naturopathic Medicine
Health Quizzes
Levofloxacin, Levaquin, Tavanic, Cravit


Levofloxacin is a fluoroquinolone antibiotic.

Levofloxacin is the S-enantiomer (L-isomer) of ofloxacin, and has approximately twice the potency of ofloxacin.


antibiotic, fluoroquinolone


Levofloxacin is effective against a number of gram-positive and gram-negative bacteria.

Levofloxacin is currently the only respiratory fluoroquinolone approved by the US FDA for the treatment of nosocomial pneumonia.

Side Effects

Both GI and CNS adverse reactions occur to a lower frequency with levofloxacin than with ofloxacin. Elevated hepatic enzymes, eosinophilia, and leukopenia have been reported.

Drug-Vitamin-Herb Interactions

Negative interactions:

Fennel may reduce levels of ciprofloxacin, possibly impairing its effectiveness.

St JohnÕs Wort and Dong quai
St JohnÕs Wort and Dong quai increase sensitivity to sunlight, adding to the side effect oc fluoroquinolones.

Calcium may interfere with absorption. Take at a different time of day.

Iron may interfere with absorption. Take at a different time of day.

Zinc may interfere with absorption. Take at a different time of day.

Positive interactions:

Lactobacillus acidophilus
Probiotics replace normal intestinal bacteria, which may reduce the side effect of diarrhea associated with antibiotics.

Sacchromyces boulardii
Sacchromyces boulardii may prevent antibiotic-related diarrhea.

Vitamin K
Antibiotics may cause vitamin K deficiency by destroying the beneficial bacteria that produce it.




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