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Isocarboxazid, Marplan

Description

Isocarboxazid is a non-selective hydrazine-derived monoamine oxidase (MAO) inhibitor used in treatment resistant depression.

Action

MAO inhibitor

Indications

depression

Side Effects



Drug-Vitamin-Herb Interactions


Negative interactions:

Asian ginseng
One report reported that Asian ginseng (Panax) combined with phenelzine caused headaches and trembling.

Ephedra
Ephedra contains ephedrine. MAO inhibitors block the degradation of epinephrine. Combining both may cause hypertension.

Green tea
Green tea contains caffeine which promotes the release of catecholamines (epinephrine and norepinephrine).

5-HTP
5-HTP may increase the risk of serotonin syndrome associated with MAO inhibitors.

SAMe
SAMe may increase the risk of serotonin syndrome associated with MAO inhibitors.

Scotch broom
Scotch broom contains tyramine, which can elevate blood pressure when combined with MAO Inhibitors.

St JohnÕs Wort
St JohnÕs Wort may elevate serotonin levels, which increases the risk of serotonin syndrome associated with MAO Inhibitors.


Positive interactions:

Vitamin B6
MAO inhibitors attach to and disable vitamin B6.

 

 

 

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