Natural Health Research

Naturopathic Medicine
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Hyzaar, HCTZ & Losartan


Hyzaar is a combination of losartan (an angiotensin II receptor antagonist) and hydrochlorothiazide (athiazide diuretic).


thiazide diuretic



Side Effects

agranulocytosis, anorexia, aplastic anemia, azotemia, blurred vision, constipation, diarrhea, dizziness, exfoliative dermatitis, glycosuria, headache, hemolysis, hypercalcemia, hypercholesterolemia, hyperglycemia, hypertriglyceridemia, hyperuricemia, hypochloremia, hypokalemia, hypomagnesemia, hyponatremia, hypotension, impotence, interstitial nephritis, jaundice, leukopenia, nausea/vomiting, orthostatic hypotension, pancreatitis, pancytopenia, paresthesias, photosensitivity, polyuria, Stevens-Johnson syndrome, thrombocytopenia, toxic epidermal necrolysis, vertigo, weakness, xanthopsia,

Drug-Vitamin-Herb Interactions

Negative interactions:

Thiazide diuretics promote calcium retention, which increases levels.

Licorice contains glycyrrhizin which promotes potassium loss, adding to the side effects of thiazide diuretics.

St JohnÕs Wort and Dong quai
St JohnÕs Wort and Dong quai may cause sensitivity to sunlight, adding to side effect of loop diuretics.

Positive interactions:

Magnesium, Potassium and Zinc
Thiazide diuretics promote magnesium, potassium and zinc loss, possibly leading to deficiency.




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