Natural Health Research

Naturopathic Medicine
Health Quizzes
Hydralazine, Apresoline, Hydra-Zide


Hydralazine is an anti-hypertensive vasodilator that relaxes blood vessels (arterioles more than venules) and increasing the supply of blood and oxygen to the heart while reducing its workload. It is commonly used in the condition of pregnancy called preeclampsia.


antihypertensive vasodilator



Side Effects

agranulocytosis, angina, anorexia, arthralgia, constipation, diarrhea, dizziness, edema, fever, fluid retention, glomerulonephritis, headache, hypotension, leukopenia, lupus-like symptoms, lymphadenopathy, nausea/vomiting, neuritis, orthostatic hypotension, palpitations, paresthesias, pericarditis, proteinuria, pruritus, sinus tachycardia, sodium retention, urticaria, weakness,

Drug-Vitamin-Herb Interactions

Negative interactions:

Coleus relaxes blood vessels, which may result in unpredictable effects on blood pressure when combined with Hydralazine.

Positive interactions:

Coenzyme Q10
Several drugs that are used to lower blood pressure (especially propanolol) may inhibit the actions of enzymes containing CoQ10.

Vitamin B6
Hydralazine attaches to and disables vitamin B6.




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