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Heparin, UFH, Unfractionated heparin

Description

Heparin is a heterogeneous group of straight-chain anionic mucopolysaccharides, called glycosaminoglycans having anticoagulant properties.

Action

anticoagulant, blood-thinner

Indications

Heparin Sodium Injection, USP is indicated for:

* Anticoagulant therapy in prophylaxis and treatment of venous thrombosis and its extension.
* In a low-dose regimen for prevention of post-operative deep venous thrombosis and pulmonary embolism in patients undergoing major abdomino-thoracic surgery or who for other reasons are at risk of developing thromboembolic disease (see DOSAGE AND ADMINISTRATION).
* Prophylaxis and treatment of pulmonary embolism.
* Atrial fibrillation with embolization.
* Diagnosis and treatment of acute and chronic consumptive coagulopathies (disseminated intravascular coagulation).
* Prevention of clotting in arterial and cardiac surgery.
* Prophylaxis and treatment of peripheral arterial embolism.
* As an anticoagulant in blood transfusions, extracorporeal circulation, dialysis procedures and in blood samples for laboratory purposes.



Side Effects

bleeding, hematuria, hyperkalemia, injection site reaction, intraocular hemorrhage, osteoporosis, peripheral neuropathy, skin necrosis, thrombocytopenia, white-clot syndrome,

Hemorrhage

Hemorrhage is the chief complication that may result from heparin sodium therapy (see WARNINGS). An overly prolonged clotting time or minor bleeding during therapy can usually be controlled by withdrawing the drug (see OVERDOSAGE). It should be appreciated that gastrointestinal or urinary tract bleeding during anticoagulant therapy may indicate the presence of an underlying occult lesion. Bleeding can occur at any site but certain specific hemorrhagic complications may be difficult to detect:

(a) Adrenal hemorrhage, with resultant acute adrenal insufficiency, has occurred during anticoagulant therapy. Therefore, such treatment should be discontinued in patients who develop signs and symptoms of acute adrenal hemorrhage and insufficiency. Initiation of corrective therapy should not depend on laboratory confirmation of the diagnosis, since delay in an acute situation may result in the patient's death.

(b) Ovarian (corpus luteum) hemorrhage developed in a number of women of reproductive age a receiving short- or long- term anticoagulant therapy. This complication, if unrecognized, may be fatal.

(c) Retroperitoneal hemorrhage.

Local Irritation

Local irritation, erythema, mild pain, hematoma or ulceration may follow deep subcutaneous (intrafat) injection of heparin sodium. These complications are much more common after intramuscular use, and such use is not recommended.

Hypersensitivity

Generalized hypersensitivity reactions have been reported, with chills, fever and urticaria as the most usual manifestations, and asthma, rhinitis, lacrimation, headache, nausea and vomiting, and anaphylactoid reactions, including shock, occurring more rarely. Itching and burning, especially on the plantar site of the feet, may occur. Thrombocytopenia has been reported to occur in patients receiving heparin sodium with a reported incidence of 0 to 30%. While often mild and of no obvious clinical significance, such thrombocytopenia can be accompanied by severe thromboembolic complications such as skin necrosis, gangrene of the extremities that may lead to amputation, myocardial infarction, pulmonay embolism, stroke and possibly death.( See WARNINGS and PRECAUTIONS.)

Certain episodes of painful, ischemic and cyanosed limbs have in the past been attributed to allergic vasospastic reactions. Whether these are in fact identical to the thrombocytopenia-associated complications remains to be determined.

Miscellaneous

Osteoporosis following long-term administration of high-doses of heparin sodium, cutaneous necrosis after systemic administration, suppression of aldosterone synthesis, delayed transient alopecia, priapism and rebound hyperlipemia on discontinuation of heparin sodium have also been reported. Significant evaluations of aminotransferase (SGOT [S-AST] and SGPT [S-ALT]) levels have occurred in a high percentage of patients (and healthy subjects) who have received heparin sodium.

Drug-Vitamin-Herb Interactions


Negative interactions:

Garlic
Garlic is natural blood thinner, which may cause excessive thinning of the blood. Monitor PT and INR regularly.

Ginkgo biloba
Ginkgo is natural blood thinner, which may cause excessive thinning of the blood. Monitor PT and INR regularly.

Phosphatidylserine
Phosphatidylserine may enhance heparinŐs blood-thinning effects.

Policosanol
Policosanol could potentiate the actions of heparin, possibly causing excessive blood thinning.

Vitamin C
Test tube studies show high doses of vitamin C may reduce the blood-thinning effects of heparin.

White willow
White willow contains a substance converted into aspirin which can cause excess blood thinning.

Natural blood thinners: Chamomile, Coleus, Dan shen, DevilŐs claw, Dong guai, Feverfew, Ginger, romelain, papain, fish oils, OPCs, vitamin E, Horse chestnut, Red clover, Reshi
Natural blood thinners may cause excessive thinning of the blood. Monitor PT and INR regularly.

Bromelain
Bromelain may increase the risk of abnormal bleeding


Positive interactions:

Vitamin D
Heparin may interfere with vitamin D metabolism, potentially causing osteoporosis.

What's your next step?

The next step, after you have been diagnosed with a disease, is to find out what is the specific cause, and then choose supplements that address it. Phone consults are my specialty. Please call my at (239) 659-2684 to schedule a consultation.

The choice is yours

I recommend that you make an informed choice, and the goal of this web site is to provide you with the information to make a wise choice when it comes to your health and wellness.

As you can see, I don't sell any vitamins on this web site. There are thousands of vitamin stores that will sell you whatever vitamin you want, and many of them offer discounts.

If you are interested in some high-quality basic nutritional supplements, I recommend visiting the Store You will find my recommendations for a multiple, tasty chewable fiber wafers, high-potency probiotics, and fish oils.

Good luck in your journey towards health and wellness!!

Why don't you tell me what vitamins to take for this disease?

Unfortunately, that would be a clear violation of FDA regulations. Also, one of the most important aspect of naturopathy is: "Treat the person, not the disease". This is a profound statement, and many people have spent thousands of dollars on vitamins listed in books or web sites for a specific disease. This is what I call "vending machine medicine". It rarely works! The solution is to find a naturopathic physician, such as myself, to assist you.


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Ronald Steriti, ND, PhD
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Call today (239) 659-2684

Information on this site is provided for informational purposes only and is not meant to substitute for the advice provided by your own physician or other medical professional. You should not use the information contained herein for diagnosing or treating a health problem or disease, or prescribing any medication. If you have or suspect that you have a medical problem, promptly contact your health care provider. Information and statements on this site have not been evaluated by the Food and Drug Administration.

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