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Naturopathic Medicine
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Glyburide, DiaBeta, Glynase, Micronase, Glibenclamide, Euglucon


Glyburide is a sulfonylurea anti-diabetic drug used in the treatment of type II diabetes.

Glyburide works by inhibiting ATP-sensitive potassium channels in pancreatic beta cells., which causes cell membrane depolarization, opening of voltage-dependent calcium channels, thus triggering an increase in intracellular calcium into the beta cell which stimulates insulin release.


antidiabetic, sulfonurease


diabetes mellitus

Side Effects

agranulocytosis, anemia, aplastic anemia, cholestasis, erythema, hemolysis, hypoglycemia, hyponatremia, jaundice, leukopenia, maculopapular rash, nausea/vomiting, pancytopenia, photosensitivity, pruritus, SIADH, thrombocytopenia, urticaria,

Drug-Vitamin-Herb Interactions

Negative interactions:

Ipriflavone may increase the effects of antidiabetics which may cause hypoglycemia.

Potassium citrate
Potassium citrate may decrease levels of sulfonylurea antidiabetic drugs.

St JohnÕs Wort and Dong quai
St JohnÕs Wort and Dong quai may cause sensitivity to the sun, adding to side effect of antidiabetics.

Mixed interactions:

Chromium improves blood sugar control, which may cause hypoglycemia with antidiabetic agents.

Ginseng lowers blood sugar levels, which may cause hypoglycemia with antidiabetic agents.

Diabetes may cause low levels of magnesium.

Magnesium increases the absorption of sulfonylurea antidiabetics.

Magnesium lowers blood sugar levels, which may cause hypoglycemia if used with antidiabetic agents.

Vanadium has an insulin-like action, which may cause hypoglycemia if used with antidiabetic agents.

Vitamin E
Antidiabetic supplements - Lipoic acid, Carnitine

Antibiabetic Herbs: Aloe, Bitter mellon, Bilberry, Burdock, Dandelion, Fenugreek, Garlic, Gymnema
Antibiabetic herbs may cause hypoglycemia if used with antidiabetic agents.

Antibiabetic Supplements: Lipoic acid, Carnitine
Antibiabetic supplements may cause hypoglycemia if used with antidiabetic agents.

Positive interactions:

Calcium corrects vitamin B12 malabsorption caused by metformin and phenformin.

Coenzyme Q10
Antidiabetic drugs interfere with the activity of enzymes containing CoQ10.

Vitamin B12
Metformin and phenformin cause malabsorption of vitamin B12.




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