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Gabapentin, Neurontin

Description

Gabapentin is a GABA antagonist used for the treatment of epilepsy and to relieve pain, especially neuropathic pain.

Action

anticonvulsant, GABA antagonist

Indications

partial seizures,

Side Effects

amblyopia, amnesia, anorexia, anxiety, arthralgia, asthenia, ataxia, back pain, blurred vision, constipation, depression, diplopia, dizziness, drowsiness, dysarthria, dyspepsia, fatigue, flatulence, gingivitis, glossitis, hypertension, impotence, leukemia, malaise, nystagmus, paresthesias, pharyngitis, pruritus, purpura, rhinitis, tremor, vertigo, weight gain, xerostomia,

Drug-Vitamin-Herb Interactions


Negative interactions:

Ginkgo biloba
Ginkgo leaves contain small amounts of a natural nerve toxin.

Glutamine
Glutamine forms glutamate which acts as a neurotransmitter.

Grapefruit juice
Grapefruit juice slows the breakdown of several drugs, including carbamezapine.

Ipriflavone
Ipriflavone - inhibits breakdown of carbamezapine and phenytoin, may cause toxic build up

Sedative herbs (Kava, Valerian, Hops)
Sedative herbs may add to depressant side-effect of anticonvulsants.

Niacinamide
Nicotinamide (Niacinamide) increases levels of carbamezapine and primidone, which may cause a toxic build up.

St JohnÕs Wort and Dong Quai
St JohnÕs Wort and Dong Quai may add to side effect of sun sensitivity.

Vitamin A
Valproic acid may interfere with the ability to handle vitamin A (beta carotene is fine).

White willow
High doses of aspirin increases phenytoin levels and toxicity. White willow contains salicylates (theoretical effect).

Folate
High levels of folate may increase breakdown of phenytoin (which may cause excess seizures)


Mixed interactions:

Biotin
Anticonvulsants may deplete biotin by competeing for absorption. Take at different times of the day.

Folate
Anticonvulsants deplete folate.


Positive interactions:

Calcium
Anticonvulsants impair calcium absorption. Take at different times of the day.

Carnitine
Anticonvulsants (especially valproic acid) deplete carnitine.

Vitamin D
Anticonvulsants may interfere with vitamin D activity and cause deficiency.

Vitamin K
Anticonvulsants speed up breakdown of vitamin K, leading to deficiency and bleeding.

 

 

 

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