Natural Health Research

Naturopathic Medicine
Health Quizzes
Famotidine, Mylanta, Pepcid, Pepcidine


Famotidine is a histamine H2 antagonist that inhibits stomach acid production.


H2 antagonist, decreases stomach acid


Famotidine is commonly used in the treatment of peptic ulcer disease (PUD) and gastroesophageal reflux disease (GERD/GORD).

Side Effects

abdominal pain, agitation, alopecia, constipation, delirium, depression, diarrhea, dizziness, hallucinations, headache, impotence, insomnia, libido decrease, nausea/vomiting, paranoia, pruritus, urticaria,

Drug-Vitamin-Herb Interactions

Negative interactions:

Magnesium (often found in antacids) may reduce the absorption of H2 antagonists. Take at a different time of day.

Positive interactions:

Folate absorption is best in an acidic environment. H2 antagonists reduce stomach acid which can lower folate absorption.

Vitamin B12
Vitamin B12 absorption may be impaired by H2 antagonists, which reduce stomach acid.

Iron and Zinc
Iron and Zinc absorption is inhibited by reduced stomach acid levels.




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