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Estrogens, Climara, Estraderm, Estratab, Ogen, Vivell


The following are marketed versions of estradiol:

Oral: Estrace¨, Activella¨ (also contains a progestin), estradiol acetate, Progynova¨, estrofem¨
Transdermal: Alora¨, Climara¨, Vivelle¨, Menostar¨, Estraderm TTS¨
Ointments: Estrasorb Topical¨, Estrogel¨
Injection: Estradiol cyprionate: Lunelle¨ monthly injection, Estradiol valerate
Vaginal ointment: Estrace Vaginal Cream¨, Premarin Cream¨
Vaginal ring: Estring¨ (estradiol acetate)


estrogens, estradiol


atrophic vaginitis, breast carcinoma, hot flashes, hypogonadism, menopausal symptoms, oophorectomy, osteoporosis, ovarian failure, prostate carcinoma,

Side Effects

abdominal pain, acne vulgaris, amenorrhea, anorexia, bleeding, breast carcinoma, cholecystitis, cholelithiasis, edema, elevated hepatic enzymes, endometrial carcinoma, erythema nodosum, gynecomastia, headache, hepatitis, hepatoma, hypertension, keratoconus, libido decrease, libido increase, mastalgia, melasma, menorrhagia, nausea/vomiting, pancreatitis, thromboembolism,

Drug-Vitamin-Herb Interactions

Negative interactions:

Androstenedione increases estrogen levels, which may increase the adverse effects of estrogen therapy.

Boron may increase estrogen levels, which may increase the adverse effects of estrogen therapy.

Dong quai
Dong quai contains beta-sitosterol, a phytoestrogen, which may increase the adverse effects of estrogen therapy. Studies, however, do not support this.

Grapefruit juice
Grapefruit juice slows breakdown of estrogen.

Mixed interactions:

Ipriflavone protects bone, but may increase estrogen effect on the uterus.

Positive interactions:

Calcium and Vitamin D
Calcium and Vitamin D aid in bone growth.

Magnesium metabolism is enhanced by estrogen, which may result in a deficiency.




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