| Doxorubicin, Adriamycin, Doxil, Rubex
Doxorubicin inhibits topoisomerase II and produces free radicals, which may cause destruction of DNA, which inhibits the growth of neoplastic cells.
anthracycline antineoplastic antitumor
alopecia, anemia, back pain, cardiomyopathy, chills, conjunctivitis, dyspnea, erythema, esophagitis, exfoliative dermatitis, flushing, headache, heart failure, hypotension, injection site reaction, lacrimation, leukopenia, myocarditis, nausea/vomiting, neutropenia, pancytopenia, pericarditis, pruritus, skin discoloration, skin necrosis, stomatitis, thrombocytopenia, urine discoloration, urticaria,
Coenzyme Q10 - may reduce heart toxicity
Vitamin E may reduce heart toxicity (controversial).
Selenium, Glutathione and Vitamin C
Antioxidants may reduce heart toxicity and increase survival time.
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