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Naturopathic Medicine
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Donepezil, Aricept


Donepezil is a centrally acting reversible acetyl cholinesterase inhibitor that is used is in the treatment of Alzheimer's disease where it is used to increase cortical acetylcholine.


inhibits acetylcholinesterase in CNS


Side Effects

At least 2% of patients receiving 5mg/day experienced nausea, diarrhea, and vomiting. At least 5% of patients receiving 10mg/day experienced nausea, diarrhea, insomnia, vomiting, muscle cramps, fatigue, and anorexia.

Body as a Whole: Headache, pain (various locations), accident, fatigue, influenza, chest pain, toothache, fever, edema face, periorbital edema, hernia hiatal, abscess, cellulitis, chills, generalized coldness, head fullness, listlessness

Cardiovascular System: Syncope, hypertension, vasodilation, atrial fibrillation, hot flashes, hypotension, angina pectoris, postural hypotension, myocardial infarction, AV block (first degree), congestive heart failure, arteritis, bradycardia, peripheral vascular disease, supraventricular tachycardia, deep vein thrombosis

Digestive System: Nausea, Diarrhea, Vomiting, Anorexia, fecal incontinence, gastrointestinal bleeding, bloating, epigastric pain, eructation, gingivitis, increased appetite, flatulence, periodontal abscess, cholelithiasis, diverticulitis, drooling, dry mouth, fever sore, gastritis, irritable colon, tongue edema, epigastric distress, gastroenteritis, stomach ulcer

Endocrine: diabetes mellitus, goiter

Hemic and Lymphatic System: Ecchymosis, anemia, thrombocythemia, thrombocytopenia, eosinophilia, erythrocytopenia

Metabolic and Nutritional Systems: Weight Decrease, dehydration, gout, hypokalemia, increased creatine kinase, hyperglycemia, weight increase, increased lactate dehydrogenase

Musculoskeletal System: Muscle Cramps, Arthritis, bone fracture, muscle weakness, muscle fasciculation

Nervous System: Insomnia, Dizziness, Depression, Abnormal Dreams, Somnolence, delusions, tremor, irritability, paresthesia, aggression, vertigo, ataxia, increased libido, restlessness, abnormal crying, nervousness, aphasia, cerebrovascular accident, intracranial hemorrhage, transient ischemic attack, emotional lability, neuralgia, coldness (localized), muscle spasm, dysphasia, hostility, decreased libido, melancholia, emotional withdrawal, nystagmus, pacing

Respiratory System: Dyspnea, sore throat, bronchitis, epistaxis, postnasal drip, pneumonia, hyperventilation, pulmonary congestion, wheezing, hypoxia, pharynglitis, pleuisy, pulmonary collapse, sleep apnea, snoring

Skin and Appendages: Pruritus, diaphoresis, urticaria, dermatitis, erythema, skin discoloration, hyperkeratosis, alopecia, fungal dermatitis, herpes zoster, hirsutism, skin striae, night sweats, skin ulcer

Special Senses: Cataract, eye irritation, vision blurred, dry eyes, glaucoma, earache, tinnitus, blepharitis, decreased hearing, retinal hemorrhage, otitis externa, otitis media, bad taste, conjunctival hemorrhage, ear buzzing, motion sickness, spots before eyes

Urogenitial System: Frequent Urination, urinary incontinence, nocturia, dysuria, hematuria, urinary urgency, metrorrhagia, cystitis, enuresis, prostate hypertrophy, pyelonephritis, inability to empty bladder, breast fibroadenosis, fibrocystic breast, mastitis, pyuria, renal failure, vaginitis

Other Side Effects: Abdominal pain, agitation, cholecystitis, confusion, convulsions, hallucinations, heart block, hemolytic anemia, hyponatremia, pancreatitis, and rash

Drug-Vitamin-Herb Interactions




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