Natural Health Research

Naturopathic Medicine
Health Quizzes
Diphenoxylate, Lomotil


Diphenoxylate is an opioid agonist used for the treatment of diarrhea that acts by slowing down intestinal contractions.

Diphenoxylate is potentially habit-forming, particularly in high doses or when long time usage is involved. Because of this, diphenoxylate is manufactured and marketed as a combination drug with atropine (Lomotil).

Diphenoxylate is classifed as a Schedule V under the Controlled Substances Act by the Food and Drug Administration (FDA) and the DEA in the United States when used in preparations. When diphenoxylate is used alone, it is classified as a Schedule II.


antidiarrheal, opiod receptor antagonist



Side Effects

abdominal pain, adynamic ileus, anorexia, depression, dizziness, drowsiness, euphoria, headache, malaise, nausea/vomiting, pancreatitis, respiratory depression, restlessness, toxic megacolon, xerostomia,

Drug-Vitamin-Herb Interactions




Fantastic new books!

Complementary and Alternative Medical Lab Testing is chock full of references for over 100 diseases.

Nutritional Genetics is also a referenced resource with sections on over 100 diseases.

Great Health Quotes has wonderful quotations about health, healing, disease, doctors, and medicine, and it's FREE.

A Brief Introduction to Naturopathy and Naturopathic Medicine describes the history and modalities. It's also FREE.



Natural Health







Information on this site is provided for informational purposes only and is not meant to substitute for the advice provided by your own physician or other medical professional. You should not use the information contained herein for diagnosing or treating a health problem or disease, or prescribing any medication. If you have or suspect that you have a medical problem, promptly contact your health care provider. Information and statements on this site have not been evaluated by the Food and Drug Administration.