Natural Health Research

Naturopathic Medicine
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Desipramine, Norpramin, Pertofrane


Desipramine is a tricyclic antidepressant


tricyclic antidepressant


Side Effects

abdominal pain, adynamic ileus, agranulocytosis, anorexia, anxiety, blurred vision, breast enlargement, confusion, constipation, cycloplegia, diarrhea, dizziness, drowsiness, EEG changes, eosinophilia, erythema, fever, galactorrhea, gynecomastia, heart failure, hypertension, impotence, increased intraocular pressure, jaundice, leukopenia, libido decrease, mydriasis, myocardial infarction, nausea/vomiting, orgasm dysfunction, orthostatic hypotension, palpitations, parkinsonism, photosensitivity, PR prolongation, pruritus, purpura, QT prolongation, sedation, seizures, SIADH, stroke, testicular swelling, thrombocytopenia, tremor, urinary retention, urticaria, vasculitis, ventricular tachycardia, withdrawal, xerostomia,

Drug-Vitamin-Herb Interactions

Negative interactions:

Sedative herbs: Kava, Passionflower, Hops, Ashwagandha, Calendula, Catnip, LadyÕs Slipper, Lemon Balm, Sassafras, Skullcap, and Yerba mansa.
Sedative herbs may cause excess sedation when used with tricyclic antidepressants.

St JohnÕs Wort and Dong quai
St JohnÕs Wort and Dong quai may cause sensitivity to sunlight, adding to side effect of tricyclic antidepressants.

5-HTP increases levels of serotonin, which increases the risk of serotonin syndrome.

SAMe increases levels of serotonin, which increases the risk of serotonin syndrome.

St JohnÕs Wort
St JohnÕs Wort may increase levels of serotonin, which increases the risk of serotonin syndrome.

Mixed interactions:

Grapefruit Juice
Grapefruit Juice slows breakdown of several drugs, including tricyclic clomipramine.

Positive interactions:

Coenzyme Q10
Tricyclic antidepressants may interfere with enzymes containing CoQ10.




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