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Cyclosporine, Neoral, Sandimmune

Description

Neoral is an oral formulation of cyclosporine that immediately forms a microemulsion in an aqueous environment.

Cyclosporine, the active principle in Neoral, is a cyclic polypeptide immunosuppressant agent consisting of 11 amino acids. It is produced as a metabolite by the fungus species Beauveria nivea.

Action

immune suppressant

Indications

Neoral is indicated for the prophylaxis of organ rejection in kidney, liver, and heart allogeneic transplants. Neoral has been used in combination with azathioprine and corticosteroids.

Rheumatoid Arthritis: Neoral is indicated for the treatment of patients with severe active, rheumatoid arthritis where the disease has not adequately responded to methotrexate. Neoralñ can be used in combination with methotrexate in rheumatoid arthritis patients who do not respond adequately to methotrexate alone.

Psoriasis: Neoralñ is indicated for the treatment of adult, nonimmunocompromised patients with severe (i.e., extensive and/or disabling), recalcitrant, plaque psoriasis who have failed to respond to at least one systemic therapy (eg., PUVA, retinoids, or methotrexate) or in patients for whom other systemic therapies are contraindicated, or cannot be tolerated.

Side Effects

abdominal pain, anorexia, azotemia, confusion, depression, diarrhea, elevated hepatic enzymes, gingival hyperplasia, headache, hirsutism, hyperkalemia, hypertension, hyperuricemia, interstitial nephritis, nausea/vomiting, paresthesias, seizures, tremor,

Drug-Vitamin-Herb Interactions


Negative interactions:

Grapefruit juice
Grapefruit juice slows the breakdown of several drugs, including Cyclosporine.

St JohnÕs Wort
St JohnÕs Wort accelerates the breakdown of several drugs, including Cyclosporine.

 

 

 

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