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Clopidogrel, Plavix

Description

Plavix (clopidogrel bisulfate) is an inhibitor of ADP-induced platelet aggregation acting by direct inhibition of adenosine diphosphate (ADP) binding to its receptor and of the subsequent ADP-mediated activation of the glycoprotein GPIIb/IIIa complex.

Action

blood thinner, inhibit platelet aggregation

Indications

Plavix (clopidogrel bisulfate) is indicated for the reduction of atherothrombotic events as follows:
Recent MI, Recent Stroke or Established Peripheral Arterial Disease
For patients with a history of recent myocardial infarction (MI), recent stroke, or established peripheral arterial disease, Plavix has been shown to reduce the rate of a combined endpoint of new ischemic stroke (fatal or not), new MI (fatal or not), and other vascular death.

á Acute Coronary Syndrome
For patients with acute coronary syndrome (unstable angina/non-Q-wave MI) including patients who are to be managed medically and those who are to be managed with percutaneous coronary intervention (with or without stent) or CABG, Plavix has been shown to decrease the rate of a combined endpoint of cardiovascular death, MI, or stroke as well as the rate of a combined endpoint of cardiovascular death, MI, stroke, or refractory ischemia.

Side Effects

Chest pain; pain, generalized; purpura (red or purple spots on skin, varying in size from pinpoint to large bruises); upper respiratory infection (cough, runny nose sneezing; sore throat)

Atrial fibrillation or palpitations (irregular heartbeat); bronchitis (cough; shortness of breath); dyspnea (shortness of breath); edema (swelling of feet or lower legs); epistaxis (nosebleed); gastrointestinal hemorrhage (vomiting of blood or material that looks like coffee grounds); gout (joint pain); hypertension; syncope (fainting); urinary tract infection (frequent urination; painful or difficult urination)

Note: Incidence of gastrointestinal hemorrhage is increased in patients receiving aspirin. Approximately 0.7% of patients receiving clopidogrel have experienced gastrointestinal hemorrhage severe enough to require hospitalization.

Intracranial hemorrhage (headache, sudden severe; weakness, sudden); neutropenia, including agranulocytosis (fever, chills, sore throat, other signs of infection; ulcers, sores, or white spots in mouth); peptic, gastric, or duodenal ulcer (stomach pain, severe); skin reactions, severe (blistering, flaking, or peeling of skin); thrombocytopenia (unusual bleeding or bruising; black, tarry stools; blood in urine or stools; pinpoint red spots on skin)

Those indicating need for medical attention only if they continue or are bothersome:

Abdominal or stomach pain; arthralgia (joint pain); back pain; dizziness; dyspepsia (heartburn); flu-like symptoms (aching muscles; fever and chills; general feeling of discomfort or illness; headache); headache

Anxiety; asthenia (weakness); constipation; cough, diarrhea; fatigue; hypoesthesia or paresthesia (numbness or tingling); insomnia (trouble in sleeping); itching; leg cramps; mental depression; nausea; rhinitis (runny nose); skin rash; vomiting



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