Natural Health Research

Naturopathic Medicine
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Cisplatin, Platinol, CDDP


Cisplatin is a platinum-based chemotherapy drug used to treat various types of cancers, including sarcomas, some carcinomas (e.g. small cell lung cancer and ovarian cancer), lymphomas and germ cell tumors. It was the first member of its class, which now also includes carboplatin and oxaliplatin.


chemotherapy, platinum-based


sarcomas, some carcinomas (e.g. small cell lung cancer and ovarian cancer), lymphomas and germ cell tumors

Side Effects

anaphylactoid reactions, anemia, anorexia, azotemia, blurred vision, hearing loss, hyperuricemia, hypocalcemia, hypokalemia, hypomagnesemia, hyponatremia, hypophosphatemia, leukopenia, nausea/vomiting, nephrolithiasis, pancytopenia, peripheral neuropathy, renal tubular acidosis, thrombocytopenia, tinnitus,

Drug-Vitamin-Herb Interactions

Positive interactions:

Bismuth subsalicylate
Bismuth subsalicylate may protect against kidney toxicity.

Cisplatin depletes kidney stores of glutathione.

Magnesium and Potassium
Cisplatin-induced kidney damage leads to mineral loss.

Selenium may help protect against kidneys and bone marrow from cisplatin toxicity.

Vitamin E
Vitamin E may protect against cisplatin-induced kidney toxicity and alleviate oral mucositis.

Silybum, Vitamin C, NAC and Ginkgo
Silybum, Vitamin C, NAC and Ginkgo may protect against cisplatin-induced kidney damage.




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