Natural Health Research

Naturopathic Medicine
Health Quizzes
Celecoxib, Celebrex, Celebra


Celecoxib is a non-steroidal anti-inflammatory drug (NSAID) used in the treatment of osteoarthritis, rheumatoid arthritis, acute pain, painful menstruation and menstrual symptoms, and to reduce numbers of colon and rectum polyps in patients with familial adenomatous polyposis.


NSAID, Antirheumatic


rheumatoid arthritis, osteoarthritis

Side Effects

Edema (swelling of face, fingers, feet, and/or lower legs), skin rash, upper, respiratory tract infection (cough, fever, sneezing, sore throat), Bronchitis (congestion in chest) cough), dyspnea (shortness of breath), gastritis, (burning feeling in chest or stomach, tenderness in stomach area), gastroenteritis (severe stomach pain, diarrhea, loss of appetite, nausea,, weakness), gastrointestinal bleeding or ulceration (bloody or black, tarry, stools, vomiting of blood or material that looks like coffee grounds), influenza-like symptoms (chills. fever, muscle aches and pains), tachycardia (fast, heartbeat), unusual weight gain, Back pain, diarrhea, dizziness, dyspepsia (heartburn), flatulence, (gas), headache, insomnia (inability to sleep), nausea, pharyngitis (pain, or burning in throat), rhinitis (runny nose), sinusitis (stuffy or runny, nose, headache), stomach pain, Anxiety, anorexia (decreased appetite), arthralgia (joint or muscle pain or, stiffness), asthenia (loss of energy or weakness), blurred vision, constipation, depression, dry mouth, dysphagia (difficulty swallowing),, esophagitis (pain or burning in throat); fatigue (unusual tiredness), fever, hot flashes (sudden sweating and feelings of warmth), increased sweating, nervousness, palpitations (pounding heartbeat), paresthesias (numbness or, tingling in fingers and/or toes), somnolence (sleepiness), taste perversion, (change in sense of taste), tendonitis (joint pain or stiffness), tinnitus, (buzzing or ringing noise in ears), vertigo (dizziness), vomiting,

Drug-Vitamin-Herb Interactions

Negative interactions:

Arginine stimulates gastrin production which increases stomach acid. This can irritate the stomach.

Feverfew has similar actions. Combining Feverfew with NSAIDs may increase the risk of side effects.

Natural blood thinners: Garlic, Ginkgo, Vitamin E, Policosanol, Dong quai, Ginger, Horse chestnut, Red clover, Fish oils, and OPCs.
Natural blood thinners may increase the tendency to bleed, a side effect of NSAIDs.

Potassium, magnesium, and calcium citrate
Citrates alkalinize the urine which decrease the therapeutic effect of NSAIDs and ASA.

St JohnÕs Wort and Dong quai
St JohnÕs Wort and Dong Quai can cause sensitivity to sunlight, which may add to side effects of NSAIDs.

Positive interactions:

Cayenne may help prevent gastric bleeding.

Colostrum may help protect against ulcers caused by NSAIDs.

Folate may be depleted by NSAIDs.

Licorice (DGL)
Licorice (DGL) may help protect the stomach against gastric damage caused by NSAIDs.

Vitamin C
Vitamin C may be depleted by NSAIDs.




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