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Ronald Steriti, ND, PhD
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Information on Pemphigus vulgaris


Description

Pemphigus vulgaris is an uncommon, debilitating, potentially fatal skin disorder characterized by intraepidermal bullae that appear on normal appearing skin without surrounding inflammation.

Causes

Pemphigus is associated with HLA-A10 and HLA-DR4 antigens. There is a higher incidence among persons of Jewish or Mediterranean descent.

Pemphigus is an autoimmune disorder with specific IgG antibodies and sometimes complement which are deposited at sites of epidermal cell damage. Many medications (particularly penicillamine) can cause pemphigus.

Pemphigus may be an adverse reaction to thiol groups found in most drugs and the Allium family, which includes garlic, onions and leeks.

Serum IgG and IgA gliadin antibodies have been found to be increased in patients with pemphigus. This may be due to increased intestinal permeability . Alternatively gliadin may somehow precipitate the autoimmune process.

Dysfunctional calcium metabolism may also be present in pemphigus. The pemphigus foliaceus antigen appears to contain a calcium-sensitive epitope, and in pemphigus vulgaris, alteration in the function of calcium-sensitive cadherins may play a role in the production of acantholysis.

Pemphigus may have a hormonal component. Pemphigus is also associated with pregnancy, and studies have shown increased levels of estradiol and reduced ones of testosterone. Lowered DHEA levels have also been found. DHEA deficiency is often found in autoimmune diseases, and may contribute to their etiology and/or pathophysiology. Increased levels of ACTH and hydrocortisone have been found in patients with pemphigus.

Conventional Labs

Autoantibody titers (by immunofluorescent studies) are routinely ordered. Titer corresponds to severity of the disease.

Causative antigens are located on the exterior surface of the cytoplasmic membrane of epithelial cells. Biopsy shows acantholytic intraepidermal bullae. Light microscopy shows suprabasal cleft formation and acantholysis (tumor formed by proliferation of epithelial squamous cells).

Specialty Lab Tests

Detoxification Profile, Standard
Adrenocortex Stress Profile
Female Hormone Profile
Male Hormone Profile
Menopause Profile


Products to consider



Natural Therapies

Most natural health web sites put a list of herbs, vitamins and nutritional supplements along with citations from scientific studies.

Have you found this to be confusing, since there are so many to choose from?

A far simpler way is to choose a supplement from the appropriate body system, such as liver support, detoxification, etc.
A well formulated supplement works a lot better than separate vitamins and usually costs a lot less.
Please call me at (239) 659-2684 if you would like some assistance in choosing an appropriate product.

I can't diagnose or treat diseases by phone, but I can assist you in making better choices. I also can send some relevant articles to read. The first ten minutes are free (as long as you purchase from my web site).

What's your next step?

The next step, after you have been diagnosed with a disease, is to find out what is the specific cause, and then choose supplements that address it. Phone consults are my specialty. Please call my at (239) 659-2684 to schedule a consultation.

The choice is yours

I recommend that you make an informed choice, and the goal of this web site is to provide you with the information to make a wise choice when it comes to your health and wellness.

As you can see, I don't sell any vitamins on this web site. There are thousands of vitamin stores that will sell you whatever vitamin you want, and many of them offer discounts.

If you are interested in some high-quality basic nutritional supplements, I recommend visiting the Store You will find my recommendations for a multiple, tasty chewable fiber wafers, high-potency probiotics, and fish oils.

Good luck in your journey towards health and wellness!!

Why don't you tell me what vitamins to take for this disease?

Unfortunately, that would be a clear violation of FDA regulations. Also, one of the most important aspect of naturopathy is: "Treat the person, not the disease". This is a profound statement, and many people have spent thousands of dollars on vitamins listed in books or web sites for a specific disease. This is what I call "vending machine medicine". It rarely works! The solution is to find a naturopathic physician, such as myself, to assist you.


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Ronald Steriti, ND, PhD
Natural Health Coach and Consultant
Call today (239) 659-2684

Information on this site is provided for informational purposes only and is not meant to substitute for the advice provided by your own physician or other medical professional. You should not use the information contained herein for diagnosing or treating a health problem or disease, or prescribing any medication. If you have or suspect that you have a medical problem, promptly contact your health care provider. Information and statements on this site have not been evaluated by the Food and Drug Administration.

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