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Graves' Disease


Description

Graves' disease is the most common form of hyperthyroidism.



Causes

GraveÕs Disease is an an autoimmune disease caused by thyroid stimulating immunoglobulins (TSI's) of the IgG class which bind to thyrotropin (TSH) receptors on the thyroid gland. The TSI's mimic the action of TSH and cause excess secretion of T4 and T3.

Conventional Labs

Thyroid peroxidase antibodies are not normally present, so a high value usually indicates autoimmune damage to the thyroid, including HashimotoÕs thyroiditis and GravesÕ disease.

Thyroid hormones include: TSH, T4, and T3.

Reverse T3 (rT3) may also be measured. T4 can form either T3 or reverse T3.

 

 

 

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