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Alzheimer's Disease


Description

AlzheimerÕs disease is a degenerative organic mental disease characterized by progressive brain deterioration and dementia; usually occurring after age 65. The diagnosis is made on clinical grounds after ruling out treatable disorders with similar characteristics.



Symptoms of Alzheimer disease include:

memory problems

disorientation, gets lost, misplaces everyday items

less interest in activities, lability of effect

anxiety, depression, mood swings, aggression

terminal phase - apathy, incontinence, inability to communicate



Profound impairment of recent memory is a characteristic symptom of AlzheimerÕs disease.



Causes

The exact cause of AlzheimerÕs disease is unknown. Toxic beta-amyloid deposits in neuritic plaques and arteriolar walls appear critical to pathogenesis. The beta-amyloid precursor gene is localized to chromosome 21.

Several mechanisms have been proposed, including: slow virus, metals (aluminum), acceleration in normal aging, and autoimmune attack.

Risk factors include: Aging, Head trauma, Low education level, Down syndrome, Positive family history, and Inheritance of the E4 allele of apolipoprotein E gene on chromosome 19.

Conventional Labs

Conventional lab tests are used to help rule out other causes of dementia: CBC, Chemistry panel, Thyroid function studies, Folate and B-12 levels, VDRL, Urinalysis, ECG (atrial fibrillation), and HIV antibody (in selected cases).

The Apo E4 test - E4 on chromosome 19 is associated with dementia.

 

 

 

Fantastic new books!

CAM Therapies has studies on natural therapies for over 100 diseases.

CAM Labs lists lab tests for 100 diseases.

Nutritional Genetics is a fantastic resource.

 

 

 

 

 


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